Astrocyte immune responses in epilepsy
نویسندگان
چکیده
منابع مشابه
MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy
Epilepsy is a chronic clinical syndrome of brain function which is caused by abnormal discharge of neurons. MicroRNAs (MiRNAs) are small noncoding RNAs which act post transcriptionally to regulate negatively protein levels. They affect neuroinflammatory signaling, glial and neuronal structure and function, neurogenesis, cell death, and other processes linked to epileptogenesis. The aim of this ...
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Astrocytes actively shape the dynamics of neurons and neuronal ensembles by affecting several aspects critical to neuronal function, such as regulating synaptic plasticity, modulating neuronal excitability, and maintaining extracellular ion balance. These pathways for astrocyte-neuron interaction can also enhance the information-processing capabilities of brains, but in other circumstances may ...
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BACKGROUND Self-injurious behavior (SIB) is a complex condition that exhibits a spectrum of abnormal neuropsychological and locomotor behaviors. Mechanisms for neuropathogenesis could include irregular immune activation, host soluble factors, and astrocyte dysfunction. METHODS We examined the role of astrocytes as modulators of immune function in macaques with SIB. We measured changes in astr...
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ژورنال
عنوان ژورنال: Glia
سال: 2012
ISSN: 0894-1491
DOI: 10.1002/glia.22312